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Issue Info: 
  • Year: 

    1992
  • Volume: 

    9
  • Issue: 

    -
  • Pages: 

    5-20
Measures: 
  • Citations: 

    1
  • Views: 

    124
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 124

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Journal: 

ENDOCRINE REVIEWS

Issue Info: 
  • Year: 

    2009
  • Volume: 

    30
  • Issue: 

    2
  • Pages: 

    119-132
Measures: 
  • Citations: 

    1
  • Views: 

    104
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 104

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Author(s): 

Journal: 

CANCERS

Issue Info: 
  • Year: 

    2018
  • Volume: 

    10
  • Issue: 

    -
  • Pages: 

    0-0
Measures: 
  • Citations: 

    1
  • Views: 

    102
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 102

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Issue Info: 
  • Year: 

    0
  • Volume: 

    5
  • Issue: 

    1 (پی در پی 17)
  • Pages: 

    19-24
Measures: 
  • Citations: 

    0
  • Views: 

    868
  • Downloads: 

    0
Abstract: 

زمینه و هدف: مایکوباکتریوم توبرکلوزیس همچنان به عنوان شایع ترین علت مرگ های مرتبط با عوامل بیماریزای عفونی در جهان مطرح است. ریفامپین نیز از مهم ترین داروهای خط اول درمان بیماری سل می باشد. شایع ترین موتاسیون های مرتبط با مقاومت به داروی ریفامپین در مایکوباکتریوم توبرکلوزیس بر اثر جابه جایی در کدون های 531، 526 و 516 در ژن rpoB اتفاق می افتد. این مطالعه با هدف معرفی روش  (Multiplex Allele specific) PCR برای شناسایی بیماران مبتلا به سل مقاوم به ریفامپین از طریق یافتن موتاسیون های ایجادشده در ژنrpoB  صورت گرفت. روش بررسی: در این پژوهش، وجود جهش در 3 کدون ژن rpoB در 90 نمونه کشت مثبت بیماران مسلول ریوی مراجعه کننده به مرکز تحقیقات مایکوباکتریولوژی واقع در بیمارستان مسیح دانشوری تهران در سال 1387-1385 پس از انجام تست های حساسیت دارویی، بررسی گردید. برای ارزیابی جهش در 3 کدون 531، 526 و 516 از روشMAS-PCR  استفاده شد. یافته ها: بر اساس نتایج کشت، %33.3 از نمونه ها حساس و %66.6 مقاوم به دارو بودند که از این میزان نمونه مقاوم به دارو، %44.4 مقاوم به ریفامپین بودند. با استفاده از روشMAS-PCR ، %32.2 از این مقاومت ها شناسایی گردید که %43.4 دارای موتاسیون در کدون rpoB531، %34.5 دارای موتاسیون در کدونrpoB526  و 531 دارای موتاسیون در کدون  rpoB516بودند. نتیجه گیری: نتایج این مطالعه نشان داد روشMAS-PCR ، روشی دقیق و مناسب برای تشخیص سریع مقاومت به ریفامپین در نمونه های کلینیکی مایکوباکتریوم توبرکلوزیس می باشد.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 868

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Issue Info: 
  • End Date: 

    خرداد 1386
Measures: 
  • Citations: 

    2
  • Views: 

    562
  • Downloads: 

    0
Keywords: 
Abstract: 

هدف از اجرای این طرح، تعیین مجموعه ای از پروتئین های اختصاصی تومورها است که با استفاده از هدف گیری این پروتئین ها به صورت ایمونوتراپی غیر فعال یا فعال در جهت از بین بردن سلول های سرطانی اقدام شود. در این طرح با استفاده از اطلاعات علمی موجود، ژن های کاندید برای استفاده در ایمونوتراپی انتخاب و با تولید آنتی بادی های پلی کلونال و منوکلونال بر علیه پروتئین مربوطه به بررسی خصوصیات این مولکول ها پرداخته شد. در این طرح از روش های استخراج DN A ،RNA ،PCR ،Western Blot ،PAGE-SDS، الیزا، Elispot، ایمونوفلورسانس، ایمونوسیتوشیمی، ایمونوهیستوشیمی، فیوژن سلولی، کشت سلولی و تولید هیبریدوم و بسیاری دیگر روش ها استفاده گردید. در این طرح 4 مولکول Opticin Fibromadulin ،PRELP و Ror1 شناسایی گردید و مشخص شد که این مولکول ها در 100% بیماران لوسمی لنفوسیتی مزمن (CLL) عرضه می گردند و بر علیه تمام آنها آنتی بادی های پلی کلونال و منوکلونال ساخته شد. خصوصیات این مولکول ها از نظر وزن مولکولی و برخی خصوصیات دیگر مانند گلیکوزیلاسیون و فسفریلاسیون بررسی شده است و هم اکنون اثرات کشندگی این آنتی بادی ها بر روی سلول های سرطانی در حال بررسی است.

Yearly Impact:   مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 562

Issue Info: 
  • Year: 

    2019
  • Volume: 

    16
  • Issue: 

    33
  • Pages: 

    117-136
Measures: 
  • Citations: 

    0
  • Views: 

    591
  • Downloads: 

    0
Abstract: 

The aim of this research was investigate the role of analytical intelligence in career interests with mediated by academic achievement of specific subjects in students. This is a descriptive-analytical study of structural equation modeling. The population included all high school students at the mathematical, experimental and humanistic fields of Urmia. Totally 370 students were selected by cluster random sampling method and completed the analytical intelligence scale and career interests’ scale. The mean of specific lessons of mathematical, experimental and humanistic considered as an indicator of academic achievement. The data were analyzed by structural equation modeling. The findings showed analytical intelligence with mediated academic achievement at the mathematic, physics, chemistry and biology lessons has direct and indirect positive and significant effect on all aspect of vocational interests. In addition the analytical intelligence with mediated academic achievement at the islamic studies, arabic, english and persian literature lessons has an indirect negative and significant effect on all aspect of vocational interests. The findings emphasize the importance of the impact of analytical intelligence and academic achievement at the specific lessons on career interests of high school students.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 591

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Issue Info: 
  • Year: 

    2006
  • Volume: 

    7
  • Issue: 

    3 (28)
  • Pages: 

    179-186
Measures: 
  • Citations: 

    1
  • Views: 

    2009
  • Downloads: 

    0
Abstract: 

Introduction: Disorders in the expression of any gene effective in spermatogenic pathway is known as a probable cause of non-obstructive azoospermia and male infertility. The way responsible genes for sperm motility are expressed can considerably affect male fertility. Recent studies show that TSGA10 gene is effective in the natural process of spermatogenesis as protein produced by this gene in mouse results in the production of the main structure of sperm tail. Up to now, no comprehensive studies have been done on the way this gene is expressed in the infertile's testical tissue.Materials & Methods: In this study, TSGA10 mRNA expression in testicular samples of 84 patients with non-obstructive azoospermia was investigated by semi-quantitative nested RT-PCR in Avesina Infertility Clinic during 2005-6. Moreover, expression levels of TSGA10 during spermatogenesis were evaluated using Johnsen's method for histopathologic scoring of the samples. For statistical analysis, SPSS software (Version 11.2) was used. The difference between gene expressions was done based on quantitative variables by the use of t-test and covariance analysis and α<0.05 was regarded as a statistically significant value.Results: Testicular TSGA10 mRNA expression was observed in 31 patients, (36.9%), with non-obstructive azoospermia which it had a statistically significant correlation with spermatogenesis progress (p<000.0). Histopathologically, the gene had been expressed in patients with higher Johnsen's score of spermatogenesis while a lack of expression was seen in all of those with Johnsen's score less than 4.5.Conclusion: The findings indicate that TSGA10 is expressed in human testis and it is restricted to germ cells. It seems that lack of TSGA10 expression may have negative effects on spermatogenesis and on male fertility. On the other hand, determination of the timing of gene expression in a certain level of spermatogenesis may also be used to determine levels of spermatogenesis in azoospermic patients alongside histopathological findings.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 2009

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Issue Info: 
  • Year: 

    2017
  • Volume: 

    14
  • Issue: 

    70
  • Pages: 

    225-236
Measures: 
  • Citations: 

    0
  • Views: 

    767
  • Downloads: 

    0
Abstract: 

Bacteriophage is the phage which causes the microbial host to infect and coliphage is the bacteriophage which in fects Escherichia coli. The presence of coliphage in surface waters is the indication of fecal contamination (enteric viruses). The objective of this study was evaluation of enteric viruses recovery from farmed fish using Male specific coliphage (MS2) as an indicator bacteriophage for enteric viruses due to stable connection to surfaces. MS2 coliphage was used to contaminate farmed Salmon fish in three concentrations (103, 105 and 108 pfu/ml) all around Mashhad city. After phage spiked, Coliphage recovery was evaluated using double agar layer technique from three different parts of Salmon fish (gills, skin flesh and interceptive) according to the best procedure (glycine- threonine- polyethylene glycol). The highest coliphage recovery in the lowest spiked concentration (103pfu/ml) was in skin-flesh of Salmon fish while interceptive of Salmon fish had the highest recovery in 105pfu/ml of spiked concentration.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 767

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Author(s): 

SAJADI S.A.M.

Issue Info: 
  • Year: 

    2007
  • Volume: 

    3
  • Issue: 

    4
  • Pages: 

    111-122
Measures: 
  • Citations: 

    0
  • Views: 

    1434
  • Downloads: 

    0
Abstract: 

Mowlana's Masnavi, the great masterpiece of Persian Poetry has been appreciated from the very beginning especially in the very recent years. As with any work of art, the possibilities of a great poem is never exhausted. It's loveliness and its significance increases, and its value to the reader increases as the reader himself continues to develop. With great Poetry, there is no saturation point: It is a 'joy for ever'. In this article attempt is made to introduce three concepts, namely "Seize the Day", "Sanctuary of God, and "Gift of friendship" drawn from the great work of Masnavi Manavi. The common basis of this selection is their application in everyday lives of the people irrespective oftime and place.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 1434

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Author(s): 

SERVAT MANSOUR

Issue Info: 
  • Year: 

    2010
  • Volume: 

    2
  • Issue: 

    4
  • Pages: 

    89-113
Measures: 
  • Citations: 

    0
  • Views: 

    1912
  • Downloads: 

    0
Abstract: 

Studying Mowlana Jallaludin Rumi’s life or, what Sufis call, “his contract with people”, could be very instructive and illuminating. More specifically, a study of Mowlana’s attitude towards people from different walks of life, the needy, the well-to-do, family members, people outside family structure, and any other groups that are considered, by social norms, as the mass or the public, on one hands, and his outlook towards the power-that-be, the rich and his own disciples, on the other, could be even useful for the reader of the contemporary period. This article is an attempt to analyze these through examples and references.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 1912

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